If your skin has been feeling dull, dehydrated or tired, you’ve probably come across three of today’s most in-demand injectable treatments: skin boosters, Profhilo, and polynucleotides. They all promise glow, hydration and rejuvenation — but they work in completely different ways.
At Crystalline Clinic, we often see clients unsure which one to choose. So in this guide, we break down each treatment, how they work, who they’re best for, and how to decide what’s right for your skin.
What Are Skin Boosters?
Skin boosters are ultra-light hyaluronic acid injections designed purely to hydrate, plump, and smooth the skin. Unlike filler, they don’t change your facial structure. Instead, they act like a long-lasting moisturiser placed directly within the skin.
Best for:
- Dry or dull skin
- Fine crepey lines
- Uneven texture
- First-time injectable clients
- Anyone wanting a natural glow
Benefits:
- Immediate hydration
- Softer, smoother skin
- Improved luminosity
- Minimal downtime
Ideal areas:
Face, neck, chest, hands.
What Is Profhilo?
Profhilo is a next-generation injectable known as a biostimulator. It contains one of the highest concentrations of hyaluronic acid on the market but works differently from regular skin boosters.
Instead of acting like a moisturiser, Profhilo spreads under the skin and stimulates collagen and elastin, leading to firmer, tighter, and more youthful-looking skin.
Best for:
- Mild skin laxity
- Sagging around jawline or cheeks
- Fine lines due to ageing
- Clients looking for a lifting effect
Benefits:
- Improves firmness
- Boosts elasticity
- Softens lines
- Gives a “tight and glowy” look
Ideal areas:
Face and neck (very popular for jawline and lower face ageing).
What Are Polynucleotides (PN/PNN)?
Polynucleotides are rapidly becoming one of the most powerful injectable treatments in aesthetics. Derived from highly purified DNA fragments, they work by repairing and regenerating skin at a cellular level.
Where skin boosters hydrate and Profhilo stimulates collagen, polynucleotides heal.
Best for:
- Tired, damaged or stressed skin
- Dark circles
- Acne scarring
- Inflammation or sensitivity
- Early signs of ageing
- Clients wanting long-term skin health improvement
Benefits:
- Deep regeneration
- Improved skin quality and strength
- Reduced pigmentation and inflammation
- Long-lasting results
- Safe for delicate areas (like under-eyes)
Ideal areas:
Under eyes, face, neck — anywhere needing repair rather than just hydration.
Skin Boosters vs Profhilo vs Polynucleotides: Which Should You Choose?
Below is the simplest breakdown to help you decide:
| Concern | Best Treatment | Why |
|---|---|---|
| Dehydrated, dull skin | Skin Boosters | Intense hydration and glow |
| Early sagging or lack of firmness | Profhilo | Stimulates collagen + elastin |
| Damaged or fragile skin | Polynucleotides | Regenerates tissue |
| Under-eye wrinkles, hollowness or darkness | Polynucleotides | Safe + highly effective in tear troughs |
| A general “refresh” | Skin Boosters | Soft natural improvement |
| Anti-ageing prevention | Profhilo + PN combination | Lifts + repairs |
| Texture issues or scarring | PN or PN + Microneedling | Encourages deeper healing |
Do These Treatments Replace Each Other?
Not at all — they work beautifully together.
Many Crystalline clients follow a combined plan such as:
- Skin Boosters for hydration
- Profhilo for firmness
- Polynucleotides for regeneration
When used strategically, these treatments build on each other to create long-lasting, naturally enhanced skin without adding volume.
How Many Treatments Do You Need?
| Treatment | Typical Plan | Maintenance |
|---|---|---|
| Skin Boosters | 2–3 sessions, 4 weeks apart | Every 4–6 months |
| Profhilo | 2 sessions, 4 weeks apart | Every 6 months |
| Polynucleotides | 2–4 sessions, 2–3 weeks apart | 1–2 top-ups yearly |
Memberships at Crystalline often help clients maintain this routine more affordably.
Which One Gives the Fastest Results?
- Skin boosters: Immediate glow
- Profhilo: Best around 4–6 weeks
- Polynucleotides: Builds progressively for long-term improvement
If you have an event, skin boosters + a subtle Profhilo lift often create the quickest visible changes.
Who Should Avoid These Treatments?
Most people are suitable candidates, but we do avoid treatment if:
- You are pregnant or breastfeeding
- You have active infections or severe inflammation
- You have certain medical conditions (discussed during consultation)
Your practitioner will always assess suitability first.
The Crystalline Recommendation
If you’re unsure where to start:
• Choose Skin Boosters if your main goal is instant glow.
• Choose Profhilo if you want firmness and anti-ageing effects.
• Choose Polynucleotides if you want long-term regeneration, especially around the eyes.
During your consultation, we can also design a combined treatment programme tailored to your skin and your goals.
Ready to Transform Your Skin?
At Crystalline Clinic, our advanced practitioners specialise in natural, balanced and long-lasting results. Whether you’re looking for glow, lift or deeper regeneration, we’ll help guide you to the best treatment — or combination — for your skin.
Book your consultation today and begin your journey to stronger, healthier, more radiant skin.